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This issue of having little racial diversity in clinical trials is further compounded by the fact that 20% of all drugs have a variation in responses across ethnic groups
1.2 Concept of macrophage polarization Macrophage polarization is a plasticity process in which these cells adopt distinct functional states upon microenvironmental signals and it plays a central role in maintaining tissue homeostasis and driving disease progression (34)
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The melanocortin system is known to modulate pain perception and inflammatory responses, which are key components of fibromyalgia pathophysiology
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