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Originally FDA-approved for type 2 diabetes, several now carry indications for weight management and cardiovascular risk reduction

Interactions: Semaglutide delays gastric emptying, use with caution in patients receiving oral medicinal products that require rapid gastrointestinal absorption

Another integration challenge is patient selection and expectations

5.3 Acute Kidney Injury Due to Volume Depletion There have been postmarketing reports of acute kidney injury, in some cases requiring hemodialysis, in patients treated with GLP-1 receptor agonists, or ZEPBOUND [see Adverse Reactions (6.2)]