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Crown ethers are useful for dissolving ionic substances such as KMnO 4 in organic solvents such as isopropanol [(CH 3 ) 2 CHOH] (Figure 13.8 "Effect of a Crown Ether on the Solubility of KMnO")
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Studies have highlighted the role of persistent fibrosis in aged tissues, where myofibroblasts in injured tissues of aged mice acquire a sustained senescent and apoptosisresistant phenotype, exacerbating fibrosis (Hecker et al ., 2014)
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