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When the average tumor volume reached 200 mm 3 (in about 23 weeks) mice were randomized to two treatment groups, one group was fed with a methionine deficient diet containing 0.172% DL-methionine (cystine-free) and the other group was fed with a control diet containing 0.86% DL-methionine (cystine-free) ad libitum with free access to water
In Phase 2, monotherapy at 4.5 mg/week reached 10.8% at 26 weeks
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