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Low doses of ketamine induce dissociative effects that non-medical users refer to as k-land, however, very high doses those leading to more pronounced immobilizing, dissociative, and hallucinatory effects can take one down a k-hole. Contrary to a therapeutic or medical setting, illicit ketamine use can set one up for a bad trip

found that in a small cohort of PASC patients, increases in medium- and long-chain acylcarnitines were among the most pronounced changes in a plasma metabolomic experiment between healthy controls and patients with PASC [48]

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Because semaglutide slows down digestion, jumping straight to a high dose could cause significant discomfort, such as nausea or stomach upset