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In the STEP-1 trial (N=1,961), 44.2% of participants receiving semaglutide 2.4 mg reported nausea versus 17.4% on placebo, and constipation occurred in 24.2% versus 11.1% [5]

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In summary, future clinical trials should prioritize enrolling individuals at risk, followed by those in the early stages of the disease, as this offers a higher likelihood of demonstrating neuroprotective and disease-modifying effects