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According to consensus criteria, an MCAS diagnosis requires all three of the following 9: 1

Genes encoding stress and defense response-related proteins including GSTs were up-regulated consistently in infected plants (Soria-Guerra et al., 2010)

The Glucagon-like peptide-1 receptor agonist, exendin-4, ameliorated gastrointestinal dysfunction in the Wistar Kyoto rat model of Irritable Bowel Syndrome

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[1] That is a real, high-tier evidence base for a specific disease endpoint, and it is why the drug reached the market