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The 2025 IV pilot measured cardiac, hepatic, renal, thyroid, and glucose biomarkers and reported no abnormalities (Lee et al., 2025), which gives a sense of what those investigators considered worth checking

4 The major clinical criteria of clEDS are (1) skin hyperextensibility, with velvety skin texture and absence of atrophic scarring

Nez J, Perna E, Schou M, Senni M, Sharma K, Van der Meer P, von Lewinski D, Wolf D, MC Petrie

Copper peptides tend to work best in a balanced, barrier-supportive routine rather than an overly aggressive one, says Karim, so think soothing, supportive ingredients that prioritise hydration and optimal skin function

McMacken M, Shah S