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But they are collections of things Ive read that many readers may not have heard anything about - perhaps because the overall weight of media messages on these drugs is on potential benefits
Most melanotic macules are congenital, affect Caucasian individuals, may be single or multiple, have a diameter varying between 0.3cm and 3cm, tend to grow in proportion to the body growth, and are unrelated to any systemic condition.2,4 Their clinical features are not yet well-defined.1,2 The etiology of the disease still remains uncertain, but it is suggested that congenital cases may represent melanocyte hamartomas.2 Histology of the described cases of lingual melanotic macule reveals increased melanin in the basal cell layer, some pigment-laden macrophages in the dermis, normal number of melanocytes with no or a slight increase of melanin in their interior and variable degrees of hyperkeratosis.2 There are no nests of melanocytes, atypia, or alterations in the lingual tissue, and, in some cases, slight elongation of the epithelial ridges has been described.2 Also, according to Dohil et al., no similar histopathological alteration was identified in the non-affected lingual tissue.2 Our patient is an adult woman, which is uncommon when compared to other cases described
So far, two pills have been approved for use by the U.S
But the existing data, combined with what we know about GLP-1 receptor pharmacology, allows for some reasonable projections about what to expect over extended treatment periods
Diabetologia 53 , 16 (2010)
