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While the core patent in India expires in March 2026, the US patent was granted a Patent Term Extension (PTE) that pushes exclusivity to December 2031

We found that STM2457 treatment markedly enhanced the stability of nave gene mRNAs, demonstrating increased resistance to degradation (i.e., Esrrb , Pou5f1 and Nanog ) (Fig

2025;58(3):e13779

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The honest assessment: berberine is a reasonable addition to a comprehensive weight management plan, but expecting tirzepatide-level results from any supplement is unrealistic