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I., Finkelstein, D
Substance-use disorders Pre-clinical and mechanistic studies A large body of pre-clinical and mechanistic literature is available regarding the putative effects of GLP-1RAs on substance misuse (Supplementary Section 5): 24 for alcohol 59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82 , 8 for opiates 63,83,84,85,86,87,88,89 , 16 for stimulants, including cocaine and amphetamines 90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105 , and 4 for nicotine 106,107,108,109
Mediation analysis of the contribution of weight loss to MASH improvement To investigate whether semaglutide improved liver histology through weight loss or via mechanisms separate from weight, mediation analyses using natural effects models were performed
A meta-analysis of 28 trials found that Mounjaro tends to reduce body weight more than semaglutide, ranging from 11 lbs to 21 lbs with tirzepatide, compared to 6 lbs to 11 lbs for semaglutide
Over 50% quit due to cost, 36% from side effects, and most regain weight upon stopping
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