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The exogenous testosterone may alleviate glycolipotoxicity-related mitochondrial dysfunction through the regulation of key enzymes involved in glucose and lipid metabolism, including adipose triglyceride lipase (ATGL), phosphoenolpyruvate carboxykinase (PEPCK), and proteins including glucose transport protein 4 (GLUT4) (129)

During the first month of using oral Semaglutide, patients can expect gradual changes as their body adjusts to the medication

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