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Oxidative stress-induced formation of methionine sulfoxide can spontaneously react with hydroxyl radical and generates methyl radical that non-specifically and non-enzymatically methylate DNA cytosine and may affect the epigenome 38

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In the hippocampus, Doxorubicin and Cyclophosphamide treatment statistically elevated p65 NF-B expression when compared to the control group by 1.49 folds