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Blood work at 3 and 6 months post-discontinuation helps determine which supplements are still needed and which can be tapered

Clinical trials demonstrate that discontinuation of semaglutide typically results in gradual weight regain, with patients recovering approximately two-thirds of lost weight within one year of stopping treatment, according to STEP trial extension data

Some users report needing 20-50% higher nasal doses to achieve equivalent effects, though individual variation is substantial

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