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This forms an iron-LRRK2 positive feedback loop that exacerbates dopaminergic neuron apoptosis (163)

To be used by trained research professionals only

Microdosing involves using substantially lower doses than standard therapeutic regimens, falling outside approved prescribing guidance

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Owing to their effectiveness in reducing body weight, once-daily subcutaneous administration of liraglutide 3.0 mg has been approved, and once-weekly subcutaneous administration of semaglutide 2.4 mg is being investigated in phase III trials, for obesity management