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Ozempic is approved for diabetes management, while Wegovy is explicitly for weight loss
In CD8+ cytotoxic T lymphocytes (CTLs), mitochondria-derived glutarate exerts its effects by translocating to the nucleocytosolic space, where it functions as a competitive inhibitor of nuclear KG-dependent dioxygenases (such as KDM5 histone demethylases and TET enzymes)
The direct relationship between change in eGFR and change in BP was also observed at 12 weeks (Extended Data Table 3)
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