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Sexual function The IIEF-5 questionnaire, a validated questionnaire for assessing the presence and severity of ED, was administered to all patients

**Inadequate protein** - Muscle loss slows metabolism ## Results by Starting Weight ### 180 lbs Starting Weight | Timeframe | Low Responder | Average | High Responder | |-----------|---------------|---------|----------------| | 3 months | 10 lbs (5%) | 15 lbs (8%) | 22 lbs (12%) | | 6 months | 18 lbs (10%) | 27 lbs (15%) | 36 lbs (20%) | | 12 months | 22 lbs (12%) | 31 lbs (17%) | 40 lbs (22%) | ### 220 lbs Starting Weight | Timeframe | Low Responder | Average | High Responder | |-----------|---------------|---------|----------------| | 3 months | 13 lbs (6%) | 19 lbs (9%) | 26 lbs (12%) | | 6 months | 22 lbs (10%) | 33 lbs (15%) | 44 lbs (20%) | | 12 months | 26 lbs (12%) | 37 lbs (17%) | 48 lbs (22%) | ### 280 lbs Starting Weight | Timeframe | Low Responder | Average | High Responder | |-----------|---------------|---------|----------------| | 3 months | 17 lbs (6%) | 25 lbs (9%) | 34 lbs (12%) | | 6 months | 28 lbs (10%) | 42 lbs (15%) | 56 lbs (20%) | | 12 months | 34 lbs (12%) | 48 lbs (17%) | 62 lbs (22%) | ## Plateaus and Stalls ### Normal Plateau Patterns - **Week 3-4:** Water weight adjustment - **Week 8-10:** Body adapting to dose - **Dose increases:** Temporary stalls common ### Breaking Through Plateaus 1

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In yeast, assembly of FeS clusters on Grx4 requires the cytosolic FeS assembly machinery, but it is not dependent on the remaining cytosolic FeS cluster machinery