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Retatrutide doesnt directly interact with thyroid medication, but weight loss may require thyroid dose adjustment

The Two Receptor Systems: GHSR and GHRH-R The regulation of pituitary GH secretion involves two complementary receptor systems that converge on the somatotroph cells of the anterior pituitary

This multi-modal mechanism produces both glucose control and weight lossoften 5-15 kg over 6-12 months

Wegovy is FDA-approved for weight loss and management in adults with obesity or overweight who have at least one weight-related health condition (e.g., high blood pressure, diabetes), as well as adults and children ages 12 and older with obesity

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