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Among late phase trials, Lixisenatide (n = 5) showed the lowest eligibility rates (5.8% Non-Asian US) due to strict HbA1c requirements (7.510%), while Dulaglutide (n = 7) showed the highest variability (SD = 46.2%)
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In times of reduced glucose (i.e., fasting, extended exercise, ketogenic diet), the body diverts the acetyl-CoA produced from the fatty acids into ketogenesis
When side effects indicate a dosing problem Normal side effects are uncomfortable but manageable
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