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History Scientific interest in NNMT increased substantially during the early 2000s as researchers discovered its involvement in metabolic regulation, cellular methylation processes, and adipose tissue function
In UK practice, monitoring is primarily based on clinical response rather than routine blood tests, as post-treatment serum B12 measurements can be misleadingly high and may not reflect tissue levels
Why B12 Becomes More Important as We Age As we age, its harder to get Vitamin B12 from food
Adiponectin provides protective metabolic signaling and declines with adiposity, lifting a brake on inflammation and insulin sensitivity that then affects estrogen and progesterone homeostasis
doi:10.1038/nature13901
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