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Nonetheless, -KG competitors (DM-succinate and ITA) inhibit the YBX1AMPK axis in both cancer cells and 293T cells, suggesting that -KG availability may broadly determines energy sensing in human cells
Creator Pratley R.E Other Affiliation: AdventHealth Translational Research Institute, Orlando, FL, United States Crowley M.J Other Affiliation: Department of Medicine, Division of Endocrinology, Duke University Medical Center, and Durham Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT), Durham, NC, United States Gislum M Other Affiliation: Novo Nordisk A/S, Sborg, Denmark Hertz C.L Other Affiliation: Novo Nordisk A/S, Sborg, Denmark Jensen T.B Other Affiliation: Novo Nordisk A/S, Sborg, Denmark Khunti K Other Affiliation: Diabetes Research Centre, University of Leicester, Leicester, United Kingdom Mosenzon O Other Affiliation: Diabetes Unit, Department of Endocrinology and Metabolism, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel Buse J.B School of Medicine, Department of Medicine Abstract Introduction: The efficacy and safety of oral semaglutide, the first oral glucagon-like peptide-1 receptor agonist, were investigated in patients with type 2 diabetes (T2D) in the Peptide InnOvatioN for Early diabEtes tReatment (PIONEER) programme
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