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Though most GLP-1RAs are approved only for T2D, semaglutide and liraglutide are also approved for weight loss likely driven by GLP-1RAs actions on satiety and gastric emptying
1 The mechanistic pathways linking GLP-1 receptor activation to cellular resilience and healthy aging
Endocrinology and Metabolism, 34 (3), 247
(2014) 4:e479
Microglia with depleted GSH have an exacerbated ROS/RNS production, elevated pro-inflammatory cytokine release, impaired phagocytic clearance, and increased neurotoxic output (Matoba et al., 2023)
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