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Based on limited human pharmacology data, ipamorelin appears relatively selective, with less pronounced effects on cortisol and prolactin secretion compared with some other GH secretagogues though this selectivity has not been extensively validated in large human trials
Nature (2012) 486(7402):2227.10.1038/nature11053 177 SchulferABlaserMJ
All animals were housed in plastic cages and fed a conventional rodent diet (21% protein, 3% crude fiber, 7% fat, 1% vitamins, and mineral premix, and 68% yellow maize, or 2490.00 Kcal/kg) on a daily basis
In this sense, the mood-related complaints seen with semaglutide may not be unique, but rather an intensified version of whats already common in restrictive dieting
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