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Some patients feel satisfied at 1.0 mg weekly, while others benefit from reaching the full 2.4 mg dose used in major clinical trials
Off-target effects are another challenge of clinical application of small molecules
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The guidelines recognize obesity as a chronic, relapsing disease requiring lifelong care and emphasize early diagnosis and integrated, person-centered approaches combining behavioral, medical, surgical and other interventions alongside prevention and management of comorbidities, the authors wrote in guidelines, published in the medical journal JAMA
