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Local IGF-1 is produced by many peripheral tissues in autocrine and paracrine fashion, including muscle, bone, and various other cell types

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2.2.1 Mitochondrial oxidative stress and TAO Mitochondrial dysfunction: Mitochondria, pivotal for cellular energy production, are implicated in TAO due to their role in thyroid hormone synthesis and metabolism, which consume substantial energy

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Vitamin D Since over three-quarters of the worlds population is deficient in this vitamin, it is known as the sun or bone vitamin