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If significant fibrosis is confirmed, patients should be referred to a specialist to perform liver biopsy and confirm the diagnosis histologically ( Chronic inflammation is the driving force for the onset and progression of fibrosis in NASH ( 4

Buchner, Robert S

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Firstly, this research was conducted using an animal model, specifically a rat lower limb ischemia-reperfusion model, which may not entirely replicate the complex pathophysiological processes observed in clinical human conditions