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A meta-analysis of initial research showed that GLP-1s reduced the risk of major adverse cardiovascular events (MACE) in patients with type 2 diabetes (T2D) by 14%, all-cause mortality by 12%, hospital admissions for heart failure by 11%, and the composite kidney outcome by 21%
PLoS One 7(5):e36957
Pfizer moves forward a daily GLP-1 obesity pill Pfizer will advance a once-daily formulation of its oral GLP-1 obesity candidate, danuglipron, after facing multiple setbacks in the space
Some of the side effects we found, like nausea, are well known, and that shows the method is picking up a real signal, said senior author Sharath Chandra Guntuku in a press release
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