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Pharmacology & Therapeutics, 109 (3), 325-338
The peptide has a real but modest effect, in the right patient, in the right context
Glutathione levels may also go down in people who drink large amounts of alcohol or who smoke cigarettes
Evidence that the enzymes themselves can be modified by redox-related processes such as S -nitrosylation (Romero-Puertas and Sandalio 2016), in addition to the transcriptional control of the genes encoding them, emphasizes the intricacy of the checks and balances operating to maintain redox homeostasis within the cellular environment
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