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When diabetes is not managed properly, it can lead to serious health problems such as heart disease, kidney failure, and even limb amputations
In this study, the difference in body weight reduction between tirzepatide- and semaglutide-treated groups can only partly explain the improvement in insulin sensitivity, lending support to the observation that tirzepatide was associated with improvements in insulin sensitivity associated with both body weight-lowering and a potential insulin-sensitizing effects of GIP
Weight loss is gradual, with patients being able to see reductions in their physical weight after several months of adhering to their medication routine
The availability of semaglutide has coincided with a broader shift in CKD care, driven by an expanding number of therapies capable of delaying disease progression and reducing the likelihood of dialysis or kidney transplantation
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