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Therapeutic targeting of transport-mediated resistance Given the central role of efflux transporters in mediating MDR, extensive efforts have been dedicated to the development of pharmacological strategies aimed at overcoming transporter-driven drug efflux

A., Rao, S., Burdick, J

While short-term preclinical studies suggest favorable safety, chronic administration effects on angiogenesis, growth factor signaling, and tissue remodeling over years of use remain unknown

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