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Clinical trials have tested weekly doses ranging from 1 mg to 12 mg, with gradual titration used to improve tolerability and minimize gastrointestinal side effects

Previous studies of KBP-089 using pair-feeding have demonstrated a weight loss beyond what is obtained through the reduction of appetite, and have clearly indicated that this effect likely entails increased energy expenditure, or at least a maintenance of energy expenditure, despite the reduction of food intake, a parameter known to reduce energy expenditure [12, 17, 29, 43]

Switching from semaglutide to tirzepatide can be done safely, but how the transition happens matters

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