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Moreover, the number of senescent cells also increase with culture time, resulting in a loss of division capabilities, resistance to apoptosis, and the acquisition of a robust proinflammatory secretome known as the senescence-associated secretory phenotype (SASP) (Jeon et al., 2018)

Furthermore, we detected the content of malondialdehyde (MDA), a marker of lipid peroxidation, and found that TGF- treatment increased MDA content, which was mitigated in GPX4-OE cells (Sup

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As lentigo malignas often present on severely sun-damaged skin, it is frequently found amongst numerous pigmented lesions thin seborrheic keratoses, lentigo senilis, lentigines