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Gastrointestinal side effects are the most commonly reported and include: Nausea (affecting 1040% of patients, depending on the specific GLP-1 agonist) Vomiting and diarrhoea (less common than nausea but can contribute to dehydration) Constipation (due to slowed gastric emptying) Abdominal discomfort or bloating These effects are typically most pronounced during treatment initiation and following dose increases
Semaglutide has low oral bioavailability, and the tablet formulation includes an absorption enhancer (salcaprozate sodium, or SNAC) to facilitate uptake across the gastric mucosa
Results May Vary: Individual results will vary based on factors including age, baseline weight, metabolic health, genetic factors, consistency of medication use, dietary choices, physical activity levels, and other individual variables
Folic acid is absorbed in the small intestine and reduced to tetrahydrofolate (THF) with the help of the enzyme dihydrofolate reductase
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