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While they are not known to interact with Zoloft specifically, GLP-1 medications can slow down the digestive process, which may affect the absorption of any oral medications you are taking, including Zoloft
Gastrointestinal safety of semaglutide and tirzepatide vs placebo in obese individuals without diabetes: systematic review and meta-analysis
Ding, Yunpeng, et al
As GLP-1 treatment improves insulin sensitivity, this androgen excess reduces, and oestrogen-related hormonal balance often improves as a result
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