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Cross-disease comparisons suggest that these modules recur across different organ niches, but their net effects are markedly context-dependent and are jointly regulated by disease stage (acute inflammation versus chronic tissue remodeling), tissue compartment (peripheral blood versus lesional tissue), as well as the spectrum of stimuli and therapeutic exposure, thereby leading to inconsistent directional outcomes of the same pathway across different models and time windows

While most side effects are minor, contact your provider if you experience persistent joint pain, significant swelling, carpal tunnel-like symptoms that don't resolve, or any reaction that feels out of the ordinary

Likewise, in sensitive people, elevated levels of green tea catechins have been linked to liver damage (67)