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PMID: 29998800 Malinda KM, et al
Whether you're interested in injections or the recently approved oral option, semaglutide aids weight loss by mimicking GLP-1, a naturally occurring hormone that curbs appetite
Oral administration does not work: digestive enzymes destroy the peptide before absorption, leaving bioavailability below 5%
This avoids overlapping the same active drug too closely
The approval is supported by two randomized, double-blind, placebo-controlled Phase III trials that enrolled a total 1,220 patients with alopecia areata who had at least 50% scalp hair loss
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