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Fistulas are a major Crohns disease complication, and this is one of the more clinically relevant preclinical findings

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Concomitant use with central nervous-system depressants (e.g., benzodiazepines, barbiturates, opioids) could enhance sedation or respiratory depression

Green et al 26 Severe clinical abnormalities should be treated intensively with B 12 , cyanoB 12 or hydroxyB 12 : HydroxyB 12 is commonly used in Europe, often at intervals of 23 months, as it seems to have better retention than cyanoB 12