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Figure 2 4.3.2 Amplification of immune responses by released intracellular components following ferroptosis When ferroptosis leads to the rupture of chondrocytes or synovial cells, the oxidized lipid byproducts, iron ions, and damage-associated molecular patterns (DAMPs) that leak from these cells are detected by nearby immune cells
Adopted a minimal-shear preparation approach, combined with buffer optimization to limit hydrolysis and oxidation
As NADPH is insufficient in G6PD-deficient RBCs, the increased ROS are not eliminated effectively and thus cause damage to the RBCs
Improves metabolism
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