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While MOTS-c's primary downstream target, AMPK, is less prone to rapid desensitization than G-protein-coupled receptors, the principle of periodic withdrawal remains clinically relevant for preserving long-term efficacy and allowing baseline metabolic function to reassert itself between cycles

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What switching actually felt like (real-life version) When I stopped forcing myself to drink something that didnt agree with me, my days got easier

[v] Li, H., Low, Y

However, going above that amount may have beneficial impacts on the gut microbiome, as noted above in regard to promoting short-chain fatty acid-producing bacteria