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Consequently, the anti-tumor immunity elevated by radiotherapy and chemotherapy is counterbalanced or masked by the potent immune suppression promoted by HIF-1

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% MPE (% maximal possible effect) = (control group flinch number of times - experimental group flinch number of times) 100 / control group flinch number of times Statistical analysis was carried out by one-way analysis of variance (ANOVA) with a post hoc test