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The advantages of GLP-1 agonists include substantial clinical trial data supporting their efficacy and safety, FDA approval for weight management in certain populations, proven results with many users losing 15-20% or more of body weight, and effects on appetite that make caloric restriction feel natural
This, in turn, upregulates the transcription of insulin signaling-related genes (e.g., GLUT4), thereby improving insulin sensitivity in both cardiac and skeletal muscle (21)
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