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By conjugating DBCO-GRD to the surface of macrophages by a bioorthogonal process, magnetic NPs containing siRNA can be delivered to tumor cells that have an abundance of RGD receptors, facilitated by a magnetic field
Nishikawa, M., Tamada, A., Kumai, H., Yamashita, F
These findings provide new insights into how efferocytosis affects effector function and phenotype, depending on the macrophages activation state, the source of the ACs, and the repertoire of efferocytic receptors
Presented for research literature review only Abei M et al
In trials it has been administered as a weekly injection, starting with a low dose and gradually titrating upwards to minimise side effects
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