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However, GLP-1 is proteolytically cleaved by dipeptidyl peptidase 4 (DPP-4), resulting in a plasma half-life of 2 minutes, which limits its therapeutic efficacy in patients with T2DM
Bone health and nutrition also deserve attention
Remember that GLP-1 receptor agonists should not be combined with DPP-4 inhibitors, as both work on the incretin system
GHK-Cu is generally well tolerated, but some people notice mild redness, tingling, or irritation, particularly at higher concentrations
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![Structures of (a) GLP-1, (b) GIP and (c) tirzepatide [19, 88, 90]](https://www.researchgate.net/publication/370926483/figure/fig4/AS:11431281185432337@1693619320519/Structures-of-a-GLP-1-b-GIP-and-c-tirzepatide-19-88-90-Amino-acids-are.png)
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