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S-glutathionylation enhances human cystathionine beta-synthase activity under oxidative stress conditions
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As per the results obtained, clearance for the hydroxychalcone was found to be 0.0417 ml/h/kg which is the least, followed by diosgenin (0.22 ml/h/kg) and charantin (0.11 ml/h/kg), indicating higher AUC for hydroxychalcone and the highest residence time of the drug in the systematic circulation and that slower will be the decline in plasma concentration of hydroxychalcone
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The mRNA expression of acetyl-CoA acyltransferase ( acca ) ( P = 0101) and peroxisomal biogenesis factor 11 gamma ( pex11 ) ( P = 0071) in the HF/H-LC group was higher than that in the HF group by at least 80 %, but the difference was not significant
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