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Nature 534 , 213217 (2016)
Regain is driven by biological mechanisms (reduced leptin, increased ghrelin, metabolic adaptation), not lack of willpower
Bibcode:1956Sci...124..484C
This is known as hysteresis
And there's a hardship that can be rendered, but it also can be a benefit in that it may allow the enrollee to succeed on a less expensive drug, but it should not be an impediment to a patient getting the drug they actually need
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