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The purpose of the 1989 TCR is to protect public health by ensuring the integrity of the drinking water distribution system and monitoring for the presence of microbial contamination

This stability is largely attributed to its unique sequence of amino acids, which allows it to withstand relatively harsh environments, including gastric acids in vivo

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Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

This stepwise escalation aimed to enhance tolerability and minimize potential gastrointestinal side effects