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The class of medications called glucagon-like peptide-1 receptor agonists (GLP-1RAs) was first authorized in the early 2000s and includes semaglutide, which gained Food and Drug Administration (FDA) approval in 2017 for patients with Type 2 diabetes

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There are multiple weight loss and diabetes medications that use either tirzepatide or semaglutide to treat type 2 diabetes or weight-related health conditions: Both Mounjaro and Zepbound are manufactured by Eli Lilly, while Wegovy and Ozempic are made by Novo Nordisk

(2017), semaglutide reduced total daily energy intake by 24% compared to placebo after 12 weeks