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In mice treated for 4 weeks with SLU-PP-332 (Billon 2023, 10-30 mg/kg orally or IP): - Skeletal muscle : increased mitochondrial content (mitochondrial/nuclear DNA +30-50%), slow-oxidative fiber shift, increased beta-oxidation enzymatic capacity, treadmill endurance increase +45 to +70%
In several RCTs, GLP-1 receptor agonists were compared with insulin or insulin-based intensification strategies, therapies that have been associated with hyperinsulinemia and potential pro-proliferative signaling
It is widely assumed that paracetamol doses in the therapeutic range are not toxic
2013 May
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