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While B12 is generally safe, caution is needed in specific clinical situations: Lebers Disease (Hereditary Optic Neuropathy): B12 injections are generally contraindicated or should be used with extreme caution, as they may potentially aggravate optic atrophy in this rare condition

Why Retatrutide matters in metabolic research Retatrutide is being studied because it combines incretin signalling with g lucagon-receptor activity , creating a broader metabolic profile than standard GLP-1 analogues

Endocrinology and Metabolism, 34(3), 247

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