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Curcumin and (-)- epigallocatechin-3-gallate protect murine min6 pancreatic beta-cells against iron toxicity and erastin-induced ferroptosis

Examples of ototoxic drugs include certain antibiotics (eg, erythromycin [Erythrocin], clarithromycin [Biaxin], and azithromycin [Zithromax]), a number of chemotherapy drugs (eg, cisplatin [Platinol], carboplatin [Paraplatin], methotrexate [Otrexup], and vincristine [Oncovin]), loop diuretics (eg, furosemide [Lasix], bumetanide [Bumex], and ethacrynic acid [Edecrin]), acetaminophen (Tylenol), and non-steroidal anti-inflammatory drugs (NSAIDs) (eg, aspirin, ibuprofen [Advil], and naproxen [Aleve])

The translation of these findings to clinical practice requires rigorous investigation through properly designed randomised controlled trials with appropriate outcome measures and safety monitoring

NAC, N -acetylcysteine

For all three it argues the conversation should be about whether a different approach justifies the cost difference, rather than starting cheap and discovering the mismatch later